Association of Cell Cycle Expression of Ia-Like Antigenic Determinants on Normal Human Multipotential (CFU-GEMM) and Erythroid (BFU-E) Progenitor Cells With Regulation In Vitro by Acidic Isoferritins
نویسندگان
چکیده
An association has been established between human la-like antigenic determinants. expression during DNA synthesis on multipotential (CFU-GEMM) and erythroid (BFU-E) progenitor cells. and the regulatory action of acidic isoferritins in vitro. Treatment of human bone marrow cells with monoclonal anti-la (NE1 -01 1 ) plus complement inhibited colony formation of CFU-GEMM and BFU-E by 50%-70%. Reduction of colonies was similar whether bone marrow cells were exposed to anti-la plus complement. high specific activity tritiated thymidine (3HTdr). or acidic isoferritins. No further decrease was apparent with 3HTdr or acidic isoferritins after la-antigen4 CFU-GEMM or BFU-E
منابع مشابه
Relationship of cell-cycle expression of Ia-like antigenic determinants on normal and leukemia human granulocyte-macrophage progenitor cells to regulation in vitro by acidic isoferritins.
An association has been established between human Ia-like (Ia) antigenic determinants, expression during DNA synthesis on granulocyte-macrophage colony forming cells (CFU-GM) and the regulatory action of acidic isoferritins in vitro. Treatment of human bone marrow cells with monoclonal-anti-Ia-like (Ia) plus complement inhibited colony and cluster formation by approximately 50% but did not affe...
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